Gene of Streptomyces avermilitis directs the relationship of avermectins B1: B2.

摘要

The present Invention relates to polinucleotidicas molecules comprising nucleotide sequences encoding a Gene product with,Polinucleotidicas molecules that can be used to alter the quantity or ratio of 2: 1 classes of avermectins fermentation produced in cultures of S. avermitilis.The present Invention further relates to vectors, host cells and Mutant strains of S.Avermitilis into which the Gene has been Inactivated with mutated or to change the Value or amount of avermectins produced 2 classes: 1.