INDENO2,1-CQUINOLINONE AND INDENO2,1-B-ISOQUINOLINONE DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION AND USE THEREOF

摘要

The present invention relates to indeno [2,1-c] quinolinone and indeno [2,1-b] isoquinolinone derivatives represented by the general formula (1), wherein A is optionally substituted with up to two hydroxyl groups or halogen atoms, or an alkoxy or C1-4 alkoxy group. - a C2-C2 alkylenedioxy-substituted benzene or naphthalene ring; B is optionally halogen, up to two hydroxyl, nitro, amino, C 1-4 alkyl, C 1-4 alkoxy or C 1-4 alkylcarbonylamino groups, or a benzyloxy group ( A C 1-4 alkylcarbonyloxy or C 1-2 alkylenedioxy substituted benzene ring; Y is -N = CR- or -CR = N-, wherein R is -NR1R2 or -OR3, wherein R1 is hydrogen, C1-6 alkyl or phenyl, optionally amino, di (1) C 1-6 alkyl monosubstituted with C 1-4 alkylamino or C 1-4 alkylamino, or di (C 1-4 alkyl) azinoyl, hydroxyl, hydroxy (C 1-4) alkyl) amino, [di (C 1-4 alkyl) amino- (C 1-4 alkyl) (C 1-2 alkyl) amino, pyrrolidinyl, pyridinyl, piperidinyl, morpholinyl or (benzyl) -oxy) carbonylamino, monosubstituted C 1-6 alkyl, R 2 is hydrogen or C 1-4 alkyl, or R 1 and R 2 together with the intervening nitrogen atom are (C 1-4 alkyl) piperazinyl, pyrrolidinyl or 1, 2,4-triazolyl, where R3 is di (C1-C4) alkylamino a mono-substituted C 1-4 alkyl group, provided that when R is a nitrogen-containing heterocyclic group as defined above, Ring A and Ring B are unsubstituted benzene rings. The invention also provides pharmaceutically acceptable salts of the compounds. The compounds of the invention are used as antitumor drugs. ŕ