PROCESS FOR PRODUCING (15,4R)- OR (1R,4S)-4-(2-AMINO-6-CHLORO-9H-PURIN)-9-YL-2-CYCLOPENTENE-1-METHANOL

摘要

the invention relates to the process of (i) or the formula (ii) or (1s, 4r) - (1r, 4s) - 4 - (2 - aminu0151 - 6 - chlorine - 9h - pu0171rin - 9 - yl) - 2 - ciklu0151pentu00e9n - 1 - metanu0151lelu0151u00e1llu00edtu00e1su00e1ra.these compounds are produced by hu0151gy u0151ly mu00f3du0151n, (+) - 2 - azabiciklu0151 [2.2.1] hept-2-en - 3 - 5 - i - you u00e1ltalu00e1nu0151s formula (iv), (+) - 2 - azabiciklu0151 [2.2.1] - hept-2-en - 5 - 3 - you - - i acilezik moiety, ahu0151l aku00e9pletben r1 is alkyl szu00e9natu0151mu0151s report 1 - 4, 1 - 4 szu00e9natu0151mu0151s alku0151xi -.aryl - or aryl - u0151xi - csu0151pu0151rt; then the kapu0151tt compound (v) u00e1ltalu00e1nu0151sku00e9pletu0171 ciklu0151pentu00e9nszu00e1rmazu00e9kku00e1 redu0171ku00e1lju00e1k; then the kapu0151ttvegyu00fcleteket - - - a n acetilaminu0151 alku0151hu0151l enzimmikru0151u0151rganizm hidru0151lu00e1z effectby means of a u0171su00e1nak or penicillin g - acilu00e1zsegu00edtsu00e9gu00e9vel (vi) or (vii) will be converted to compound formula akapu0151tt vegyu00fcletetet; - n - (2 - aminu0151 - 4.6 - dichloro pyrimidine) - 5 - (1s, il - fu0151rmamiddal(1r, 4r) - (4s) - 4 - [2 - aminu0151 - 6 - chloro - 5 - 4 - fu0151rmamidu0151 pirimidinil) - aminu0151] - 2 - ciklu0151pentu00e9n - 1 - metanu0151llu00e1 shape; and the kapu0151ttvegyu00fcleteket (formula (i) or (ii) compounds ciklizu00e1lju00e1k.in accordance with the procedure laid down atalu00e1lmu00e1ny kapu0151tt compounds, intermediate products aminu0151 - 2 - pu0171rin - a nu0171kleu0151zidu0151k elu0151u00e1llu00edtu00e1su00e1hu0151z may be used.