Pharmaceutical compositions comprising a supported saccharide for the treatment of travellers' diarrhea caused by E.coli LT enterotoxin

摘要

This invention relates to treatment of traveller's diarrhea, including diarrhea caused by enterotoxogenic Escherichia coli (ETEC), using an oligosaccharide-containing composition. The composition contains an oligosaccharide sequence covalently attached to a pharmaceutically acceptable solid, inert support through a non-peptidyl compatible linker arm. The oligosaccharide-containing composition binds E. coli heat-labile toxin (LT). More specifically, the invention concerns neutralization and removal of LT associated with traveller's diarrhea.