Cosmetic, dermatological and / or therapeutic method to alter (promote or inhibit) the pigmentation of the skin and / or hair of a human being, pharmaceutical / cosmetic / dermatological composition that alters the pigmentation of the skin and / or human hair with topical application and in vitro method for selecting compound or compound combination that alter (increase or decrease) the pigmentation of human skin and / or hair

摘要

An in vitro assay for selecting compounds that alter pigmentation of skin is provided. Also, a novel class of pro-pigmentatory compounds is provided which comprise substituted aromatic or heterocyclic carboxylic acids, or derivatives thereof, or pharmaceutically acceptable salts, which do not contain a pheno, naphthol, thiophenol, or a thionaphthol function in free or protected form. In a preferred embodiment, thess compounds will display activity for RXRs. These compounds may be used for altering pigmentation of human skin and/or hair in cosmetic or dermatological compositions, and for the treatment of disorders and disease conditions that affect skin or hair pigmentation.