Evaluation of Methods for Analysis of Human Fat, Skin, Nails, Hair, Blood and Urine

摘要

The research program surveyed and evaluated the methods and procedures to identify and quantitate chemical constituents in human tissues and fluids including fat, skin, nails, hair, blood, and urine. These methods have been evaluated to determine their ease and rapidity, as well as cost, accuracy, and precision. During this evaluation, a second goal was to determine the feasibility of correlating a preferred method with a specific tissue/fluid and with easily identifiable chemical characteristics, such as octanol-water partition coefficient, water solubility, vapor pressure, etc. Because of these goals, the search strategy, as well as the literature evaluation focussed on analytical methods. The literature search was restricted to lists of chemicals of current interest to the U.S. Environmental Protection Agency, to references cited in 'Chemicals Identified in Human Biological Media, A Data Base,' and the 'Chemical Abstract Data Base'.