Method for cosmetic, dermatological and / or therapeutic for change (promote or inhibit) the pigmentation of the skin and / or of hair of a human being.The pharmaceutical composition / cosmetics / dermatological amending the pigmentation of the skin and / or of human hair with topical application and in vitro method to select the compound or combination of compoundChange (increase or decrease) the pigmentation of the skin and / or of human hair

摘要

An in vitro assay for selecting compounds that alter pigmentation of skin is provided. Also, a novel class of pro-pigmentatory compounds is provided which comprise substituted aromatic or heterocyclic carboxylic acids, or derivatives thereof, or pharmaceutically acceptable salts, which do not contain a pheno, naphthol, thiophenol, or a thionaphthol function in free or protected form. In a preferred embodiment, thess compounds will display activity for RXRs. These compounds may be used for altering pigmentation of human skin and/or hair in cosmetic or dermatological compositions, and for the treatment of disorders and disease conditions that affect skin or hair pigmentation.