Dipyridoxyl chelating agents and their metal chelates for treating free radicals induced conditions

摘要

This use of the chelating agents of the formula (I) or metal chelates thereof is in the manufacture of a therapeutic agent for use in the treatment or prophylaxis of conditions resulting from the presence of free radicals in the human or non-human animal body, particularly in relieving symptoms associated with reperfusion of ischemic tissue and in treating or preventing radiation-induced injury. The moieties of the compounds of formula (I) are defined as: each R1 independently represents hydrogen or -CH2COR5; R5 represents hydroxy, optionally hydroxylated alkoxy, amino or alkylamido; each R2 independently represents a group XYR6; X represents a bond, or a C1-3 alkylene or oxoalkylene group optionally substituted by a group R7; Y represents a bond, an oxygen atom or a group NR6; R6 is a hydrogen atom, a group COOR8, an alkyl, alkenyl, cycloalkyl, aryl or aralkyl group optionally substituted by one or more groups selected from COOR8, CONR82, NR82, OR8, =NR8, =O, OP(O) (OR8)R7 and OSO3M; R7 is hydroxy, an optionally hydroxylated, optionally alkoxylated alkyl or aminoalkyl group; R8 is a hydrogen atom or an optionally hydroxylated, optionally alkoxylated alkyl group; M is a hydrogen atom or one equivalent of a physiologically tolerable cation; R3 represents a C1-8 alkylene group, a 1,2-cycloalkylene group, or a 1,2-arylene group; and each R4 independently represents hydrogen or C1-3 alkyl).