Human DNase I variants having binding affinity to actin

摘要

These actin-resistant variants of human DNase 1, which are useful in treating pulmonary disorders, have 90% identity with the amino acid shown and have at least one amino acid substitution for another at the positions: His44, Leu45, Val48, Gly49, Leu52, Asp53, Asn56, His64, Tyr65, Val66, Val67, Ser68, Glu69 or Ala114.