SOLID PHASE SYNTHESIS OF COMPOUNDS BY CARBON-CARBON BOND FORMING MITSUNOBU REACTIONS

摘要

Processes are provided for the Mitsunobu alkylation reaction of carbon-carbonbond formation between a solid support reagent and a reagent in solution. Theresulting novel products can be prepared as a combinatorial library by high-throughput, parallel synthesis under robotic automation. Cleaved or support-bound products are useful precursors to biologically active compounds.