METHOD FOR REMODELLING AN ANIMAL GENOME BY ZYGOTIC TRANSFER OF A SITE-SPECIFIC RECOMBINASE

摘要

the present invention relates to a method for transferring in an oocyte from a- a site specific recombinase cre, in particular in itsthe active form. the recombinase is expressed under the control of a promoterspecifically in male germ cells of at least one sitespecific and are associated with sperm chromatin. this processis particularly useful in reshaping the genome of an animal, for exampleto insert a foreign sequence in the genome of an animal, andfor a sequence in another. in the case where the sponsor is thesycp1 promoter, a mode of application allows recombinationpaternal and maternal chromosomes. the present invention ison the animals which can be obtained by this process; andthe use of transgenic animals in industriespharmaceuticals, cosmetics, and food processing.