HYPERTENSION ASSOCIATED TRANSCRIPTION FACTOR-1 (HATF-1) AND HATF RELATED PROTEIN 1 (HRP-1)

摘要

The invention provides isolated nucleic acids molecules, designated HATF-1 andHRP-1 nucleic acid molecules, which are differentially expressed inhypertensive humans, rats, and mice. The invention also provides antisensenucleic acid molecules, recombinant expression vectors containing HATF-1 orHRP-1 nucleic acid molecules, host cells into which the expression vectorshave been introduced, and nonhuman transgenic animals in which an HATF-1 orHRP-1 gene has been introduced or disrupted. The invention still furtherprovides isolated HATF-1 and HRP-1 proteins, fusion proteins, antigenicpeptides and anti-HATF-1 and anti-HRP-1 antibodies. Diagnostic methodsutilizing compositions of the invention are also provided.