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HYPERTENSION ASSOCIATED TRANSCRIPTION FACTOR-1 (HATF-1) AND AND HATF RELATED PROTEIN 1 (HRP-1)
HYPERTENSION ASSOCIATED TRANSCRIPTION FACTOR-1 (HATF-1) AND AND HATF RELATED PROTEIN 1 (HRP-1)
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机译:高血压相关转录因子1(HATF-1)和与HATF相关的蛋白1(HRP-1)
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摘要
The invention provides isolated nucleic acids molecules, designated HATF-1 and HRP-1 nucleic acid molecules, which are differentially expressed in hypertensive humans, rats, and mice. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing HATF-1 or HRP-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an HATF-1 or HRP-1 gene has been introduced or disrupted. The invention still further provides isolated HATF-1 and HRP-1 proteins, fusion proteins, antigenic peptides and anti-HATF-1 and anti-HRP-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
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