Inhibitors for optic hypofunction caused by optic nerve cell injury induced byfactors other than optic circulatory disorder which contain as the activeingredient 1,4-dihydropyridine derivatives represented general formula (I) oracid addition salts thereof: wherein X1 and X2 are the same or different andeach represents hydrogen, fluoromethyl, fluoromethoxy, halogeno, cyano ornitro; R1 represents lower alkyl; R2 represents acyl, alkoxycarbonyl,acylalkyl, N-alkylated carbamoylalkyl, alkoxyalkyl, alkoxycarbonylalkyl,acyloxyalkyl, nitratoalkyl, cyanoalkyl, heterocycle-alkyl, haloalkyl, alkenylor alkynyl; A represents alkylene having at least five carbon atoms in totaland having carbon to which two alkyl groups are attached; and m is an integerof from 1 to 3.
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