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Thiazolidine and oxazolidine derivatives for the treatment of acute myocardial infarction and inhibition of cardiomyocyte apoptosis
Thiazolidine and oxazolidine derivatives for the treatment of acute myocardial infarction and inhibition of cardiomyocyte apoptosis
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机译:噻唑烷和恶唑烷衍生物用于治疗急性心肌梗塞和抑制心肌细胞凋亡
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摘要
It has been demonstrated that antidiabetic thiazolidine and oxazolidine derivatives (glitazones) exhibit novel effects on apoptosis of cardiomyocytes. These substances are capable of greatly decreasing apoptosis by a pathway that is not Caspase 3 dependent. Addition of IGF1 to the treatment further prevents apoptosis. Glitazones alone or glitazones plus IGF1 should be administered at the beginning of a myocardial infarction and continued through the recuperation period to reduce morbidity and prevent unfavorable remodeling of the myocardium.
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