首页>
外国专利>
Ion channels, in particular vanilloid receptor - like (vr-l) receptor
Ion channels, in particular vanilloid receptor - like (vr-l) receptor
展开▼
机译:离子通道,特别是类香草酸受体-(vr-1)受体
展开▼
页面导航
摘要
著录项
相似文献
摘要
The invention provides isolated non-selective cation channel proteins which are (a) activatable by noxious heat; (b) obtainable from human T lymphocytes; (c) not capsaicin sensitive, particularly the VR-L protein (Seq ID No. 2), plus or variants (e.g. homologues or fragments) thereof. Also provided are nucleic acids encoding these (e.g. Seq ID No. 1), or which have utility in probing, amplifying or down-regulating these. Methods of providing the proteins and nucleic acids are disclosed, as are vectors, host cells, and organisms utilising them, and antibodies. Also disclosed are methods of influencing the electrophysiological and/or pharmacological properties of a cell (e.g. by way of therapy) based on manipulation of the proteins or nucleic acids, and methods for screening for substances having ion-channel modulating activity (which may be potential analgesics or other compounds which affect nociception, immunomodulatory agents or neuromodulatory agents).
展开▼
机译:本发明提供了分离的非选择性阳离子通道蛋白,其可被(a)通过有毒的热量激活; (b)可从人T淋巴细胞获得; (c)对辣椒素不敏感,特别是VR-L蛋白(Seq ID No. 2),及其正反或变异体(例如同源物或片段)。还提供了编码这些核酸的核酸(例如,Seq ID No.1),或在探测,扩增或下调这些核酸中具有效用的核酸。公开了提供蛋白质和核酸的方法,以及载体,宿主细胞和利用它们的生物以及抗体。还公开了基于蛋白质或核酸的操纵来影响细胞的电生理和/或药理性质的方法(例如通过治疗),以及用于筛选具有离子通道调节活性的物质(可能是潜在的)的方法。止痛药或其他影响伤害感受的化合物,免疫调节剂或神经调节剂)。
展开▼