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LATENCY-ACTIVE REGULATORY SEQUENCES OF HERPESVIRUSES AND LATENCY-INACTIVE HERPESVIRUS FOR GENE TRANSFER
LATENCY-ACTIVE REGULATORY SEQUENCES OF HERPESVIRUSES AND LATENCY-INACTIVE HERPESVIRUS FOR GENE TRANSFER
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机译:疱疹病毒和潜伏性疱疹病毒基因转移的主动-活性调节序列
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摘要
A mutant herpesvirus has inactivating (preferably deletion) mutations at the locus of both native copies of the latency-active regulatory sequences. The resulting virus can be used as a latency-inactive virus as the basis of the vectors for gene delivery, as a helpervirus for production of amplicons, and as a base virus mutant for the construction of mutant virus vectors carrying synthetic latency-active regulatory sequences. Also described are synthetic/semisynthetic latency-active regulatory sequences and their use in CNS and other cells.
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