Preparation of a granulated substance in which the characteristic of solubility of Nimodipine is modified. A solution of the drug is prepared with substances that modify the solubility of said drug, said substances being capable of forming a solid solution with said drug. Said solution is absorbed on disintegrant substances and this humid powder is mixed, granulated through a stainless steel mesh (opening 1,5 to 2 mm), and then dried.II ― The particles of the dried granulated substance are put on a large shallow pan where a coating with polymeric substances in solution is applied by aspersion and then it is dried by blowout of hot airIII ― Compression of the coated granules in order to obtain tablets containing 60 and 90 mg of Nimodipine.展开▼
机译：制备粒状物质，其中尼莫地平的溶解性特征得到修饰。用改变所述药物溶解度的物质制备药物溶液，所述物质能够与所述药物形成固溶体。所述溶液被崩解物质吸收，并将这种湿粉末混合，通过不锈钢网（开口1.5至2mm）造粒，然后干燥。 II 将干燥的颗粒状物质的颗粒放在一个大的浅锅中，在该锅中涂上聚合物质溶液中通过散剂施用，然后通过吹入热空气干燥。 III 压缩包衣颗粒以获得含有60和90 mg尼莫地平的片剂。
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