Process for the preparation of a New formulation of long-acting Tablets comprising a Granulate which is incorporated the principle Active Nimodipine.

摘要

Process for preparing Pharmaceutical compositions containing Nimodipine programmed release,For the gradual release of principioactivo and maintaining its Therapeutic Action.With lower lasconcentracion plasma oscillations is observed with immediate formulations deliberation.The formulation comprises: preparation of Granules in Amending the solubility characteristics of Nimodipine poramasado of Drug Substance solubility and conmodificadores d eS DISINTEGRATING Granules, and subsequent drying. The application of Spray Coating on elgranulado Paila with Solutions of polymeric substances, after which it is dried.The compression delgranulado to l to obtain decomprimidos containing 60mg Nimodipine and 90mg