6,7-ASYMMETRICALLY DISUBSTITUTED QUINOXALINECARBOXYLIC ACID DERI VATIVES, ADDITION SALTS THEREOF, AND PROCESSES FOR THE PREPARATION OF BOTH

摘要

The present invention provides compounds with antagonism against excitatory amino acid receptors, in particular, AMPA receptor, having 6,7-asymmetrically disubstituted quinoxalinecarboxylic acid derivatives and their addition salts as effective ingredients, and processes for preparing them, and relates to 6,7-asymmetrically disubstituted quinoxalinecarboxylic acid derivatives represented by a general formula (1) [wherein, Q denotes a halogen atom, lower alkyl group which may be substituted with halogen atom, general formula (2)        Ar-P-     (2)(wherein Ar denotes a phenyl group or naphthyl group which may have one or more substituents, and P denotes a lower alkylene, lower alkenylene, lower alkynylene, oxygen or sulfur atom), or general formula (3);        L-A-     (3)R denotes a nitro group, trifluoromethyl group, amino group which may be substituted, or general formula (7),R¹ denotes an aralkyl group, phenyl group, naphthyl group, 5- or 6-membered heterocycle and its condensed ring (these may have one or more substituents on aromatic ring or heterocycle), hydrogen atom, lower alkyl group which may be substituted with halogen atom or cycloalkyl group, and R² denotes a hydroxyl group, lower alkoxy group or general formula (6) ], and their addition salts.