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$i(SPECIFIC) STEADY-STATE R-TYPE Ca?2+ CHANNEL BLOCKERS AND USE THEREOF
$i(SPECIFIC) STEADY-STATE R-TYPE Ca?2+ CHANNEL BLOCKERS AND USE THEREOF
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机译:$ i(特定)稳态R型Ca?2+通道阻隔剂及其使用
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摘要
The present invention relates to Ca2+ channel blockers and more particularly to the R-type Ca2+ channel blockers. More specifically, the invention relates to Ca2+ channel blockers activity of Mandevilla velutina and Mandevilla illustris. The present invention further concerns saponin-like compounds isolated from Mandevilla species. The present invention also relates to the treatment of several pathologies that involve the nifedipine-insensitive but isradipine sensitive steady-state R-type Ca2+ channel and the use of steady-state R-type Ca2+ channel blockers in the treatment of these pathologies.
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