PURPOSE: A new preparation of 4-amino-5-hexenoic acid is provided that produces economically 4-amino-5-hexenoic acid through simple processes using glutamic acid-5-benzylester as a starting material. CONSTITUTION: The preparation of 4-amino-5-hexenoic acid (vinyl γ-aminobutyric acid) comprises the step of preparing the desired compound via new intermediates of Formula (II), (III) and (IV) from glutamic acid-5-benzylester of Formula (I) derived from glutamic acid. More particularly, the preparation of 4-amino-5-hexenoic acid of Formula (A) comprises hydrolyzing 4-£(benzyloxy)carbonyl|amino-5-hexenoic acid benzyl ester £Formula (IV)| in the presence of Pd/C catalyst. The preparation of the desired compound (I) comprises the step of subjecting benzyl-4-{£(benzyloxy)carbonyl|amino}-5-oxopentanoate £Formula (III)| to a Wittig reaction. Also, the preparation of benzyl-4-{£(benzyloxy)carbonyl|amino}-5-oxopentanoate £Formula (III)| comprises the steps of reacting glutamic acid-5-benzylester £Formula (I)| with benzyl chloroformate to provide N-benzyloxycarbonyl glutamic acid-5-benzylester £Formula (II)|, and then directly reducing the compound of Formula (II) or converting the carboxyl group of the compound represented by Formula (II) to an alcohol group using NaBH4 and ethylchloroformate followed by subjecting to a Swern Oxidation.
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