integrated device for the continuation of the optical characteristics and advantages of this detection

摘要

A substrate (12) defines a binding site (14) for receiving a molecular receptor (16). A light source (18) and an optical detector (20) are incorporated in the substrate (12). The light source (18) illuminates the binding site (14) through the substrate (12) to produce an optical indication of a molecule (19) hybridized to the molecular receptor (16). The optical detector (20) detects the optical indication through the substrate (12). Preferably, the substrate (12) defines a first side on which the binding site is defined, and a second side opposite the first side on which the light source and the optical detector are integrated. A transparent electrode can be included at the binding site for field-assisted hybridization and de-hybridization.