New peptide inhibitors of human topoisomerase with high activity and specificity, for treating, for example, cancer and viral infections

摘要

Peptides (I) that inhibit human topoisomerase II alpha and their protected derivatives are new. Peptides of formula (I) and their protected derivatives are new Thr-X1-Leu-Asp-Ile-X2-X3-Asp-Leu-X4-Glu-X5-Arg-Leu-Lys-Tyr-Tyr-X6-X7-A rg-Lys-Glu-Phe-Leu-X8-X9-X10-Leu-Gly (I) X1 = Gln or Glu; X2 and X5 = Leu or Lys; X3 = Arg or Lys; X4 = Phe or Tyr; X6 = Gly or Glu; X7 and X8 = Leu or Glu; X9 = Gln or Lys; X10 = Met or norleucine An Independent claim is also included for a composition containing (I) as the active ingredient.