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New human virus-inhibiting peptide, useful e.g. for treating viral or other infections or cancer, comprises fragment of alpha1-antitrypsin
New human virus-inhibiting peptide, useful e.g. for treating viral or other infections or cancer, comprises fragment of alpha1-antitrypsin
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机译:新的人病毒抑制肽,例如用于治疗病毒或其他感染或癌症的药物,包括α1-抗胰蛋白酶的片段
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摘要
The peptide VIRIP (human virus-inhibiting peptide) and its biologically active fragments and/or variants and/or derivatives, especially amidated, acetylated, sulfated, poly(ethylene glycol)-modified, phosphorylated and/or glycosylated derivatives, also synthetic peptides with the same biological activity (collectively (I)). VIRIP has the formula (1) Z1-LEAIPMSIPPEVKFNKPF-Z2 (1) Z1 and Z2 = 0-10 amino acids, or Z1 = hydrogen and Z2 = carboxy Independent claims are also included for the following: (a) nucleic acid (II) encoding (I); (b) vector containing (II); (c) genetically modified host cell containing the vector; (d) nucleic acid (IIa) that hybridizes with (II); (e) antibody (Ab), antagonist or inhibitor of (I); (f) combination of (I) and an adapter protein that ensures uptake into virus-infected cells; (g) galenical formulation containing (I) and a carrier; (h) method for preparing (I); (i) diagnostic agent containing Ab or (II); and (j) pharmaceutical composition containing (I), (II), Ab or an antagonist/inhibitor of (I).
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