Combination gene therapy using the p53 gene

摘要

The combination of wild type p53 gene and the E1B-deleted p53 gene are suitable for the treatment of human and animal cancers. The genes may be delivered sequentially or simultaneously using adenovirus or liposomal vectors. The combination may be administered intravenously, orally, intra-arterially, intraperitoneally or directly into the tumour. The combination is cytotoxic in cancer cell lines irrespective of their p53 genotype.