This invention provides an isolated nucleic acid molecule encoding a mammalian p57.sup.KIP2. This invention also provides vectors comprising the isolated nucleic acid molecule encoding a mammalian p57. sup.KIP2. This invention further provides a host vector system for the production of a mammalian p57.sup.KIP2. This invention also provides probes for the isolated nucleic acid molecule encoding a mammalian p57. sup.KIP2. This invention provides antibodies directed against a mammalian p57.sup.KIP2. This invention also provides transgenic animals comprising isolated nucleic acid molecules encoding a mammalian p57.sup. KIP2. Finally, this invention provides different uses of the mammalian p57.sup. KIP2.
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