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Method for inducing apoptosis of primary central nervous system B cell lymphomas
Method for inducing apoptosis of primary central nervous system B cell lymphomas
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机译:诱导原发性中枢神经系统b细胞淋巴瘤凋亡的方法
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摘要
A method for treating a primary central nervous system lymphoma in an individual relates to administering intrathecally or intralesionally a therapeutically effective amount of a Fas-cross-linking composition thereby inducing the lymphoma cells to undergo Fas-mediated cytotoxicity. The Fas-cross-linking composition may be an agonist anti- human Fas monoclonal antibody or fragments thereof, soluble Fas-ligand (Fas-L), and a combination thereof. In another embodiment, the lymphoma is pretreated with a composition that enhances Fas-mediated cytotoxicity induced by a Fas-cross-linking composition, followed by treatment with the Fas-cross- linking composition.
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