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Enzymatic synthesis of chiral amines using -2-amino propane as amine donor
Enzymatic synthesis of chiral amines using -2-amino propane as amine donor
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机译:以-2-氨基丙烷为胺供体的酶法合成手性胺
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摘要
2-Aminopropane is used as the amine donor in the stereoselective synthesis of a chiral amine from a ketone with a transaminase. In a typical embodiment, (S)-1-methoxy-2-aminopropane is prepared by bringing methoxyacetone into contact with a transaminase in the presence of 2- aminopropane as an amine donor until a substantial amount of methoxyacetone is converted to (S)-1-methoxy-2-aminopropane and 2- aminopropane is converted to acetone. In a second embodiment, L- alanine is prepared by bringing pyruvic acid into contact with a transaminase in the presence of 2-aminopropane as an amine donor.
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