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Azo derivatives and use of these derivatives as drugs and anti-AIDS agents

机译:偶氮衍生物及其作为药物和抗艾滋病药物的用途

摘要

Compositions useful in methods of disinfecting contain azoic compounds of the general formula IMAGE wherein R1, R2, R3 and R4 are identical or different and each represents an atom of hydrogen or an aliphatic or aromatic hydrocarbon radical comprising from 1 to 6 carbon atoms; X1 and X2 are identical or different and each represents an oxygen atom or an NR5 group, wherein R5 is a hydrogen atom, an aliphatic or aromatic hydrocarbon radical comprising from 1 to 6 carbon atoms, or a nitro group; and wherein when two NR5 groups are simultaneously present each R5 may be identical to or different from the other. Compositions containing the azoic compounds in a liquid medium at concentrations of from 35 mu gr/ml to 2 mgr/ml are sufficient to impede replication and proliferation of viruses of the retrovirus group yet they are insufficiently toxic to destroy sound human or animal cells which come in contact with the compositions. Methods of disinfecting using the compositions are also provided.
机译:可用于消毒方法的组合物包含通式的偶氮化合物,其中R1,R2,R3和R4相同或不同,并且各自表示氢原子或包含1-6个碳原子的脂族或芳族烃基; X1和X2相同或不同,分别代表氧原子或NR5基团,其中R5为氢原子,含1至6个碳原子的脂族或芳族烃基或硝基。其中两个NR5基团同时存在时,每个R5可以彼此相同或不同。在液体培养基中浓度为35μgr/ ml至2mgr / ml的含偶氮化合物的组合物足以阻止逆转录病毒组病毒的复制和增殖,但它们的毒性不足以破坏人类或动物的健全细胞。与组合物接触。还提供了使用该组合物进行消毒的方法。

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