The condensation benzene oxy acetic acid derivative, those production manners and contains those as the active ingredient the medicine

摘要

PURPOSE: To provide a new compound having PGI₂ receptor agonistic action and useful for the prevention and treatment of thrombosis, arteriosclerosis, ischemic cardiopathy, gastric ulcer, hypertension, etc. ;CONSTITUTION: The compound of formula I [group of formula II is formula III ((e) is 3-5; (p) is 0-4), etc.; A is group of formula IV (R² is H, 1-6C alkyl or phenyl), etc.; R¹ is H or 1-4C alkyl; R³ is 1-15C alkyl, benzene ring, 4-7C cycloalkane, etc.], e.g. [2-[2-[1-phenyl-1-(4-pyridyl)methyloxyimino]-propyl]-1,2,3,4- tetrahydronaphthalen-5-yloxy]acetic acid. The compound of formula I can be produced e.g. by hydrolyzing a compound of formula V (R^1a is 1-4C alkyl).;COPYRIGHT: (C)1994,JPO&Japio