THERAPEUTIC AGENT FOR RHEUMATOID ARTHRITIS AND ARTICULAR SYNOVIOCYTE PROLIFERATION INHIBITOR

摘要

PROBLEM TO BE SOLVED: To obtain a therapeutic agent for rheumatoid arthritis and an articular synoviocyte proliferation inhibitor, especially the therapeutic agent capable of regulating the Notch gene expression of the synoviocytes in the rheumatoid arthritis, controlling the homeostasis of the synoviocytes and inhibiting the abnormal proliferation and activation of the synoviocytes. ;SOLUTION: This therapeutic agent for the rheumatoid arthritis is characterized as comprising an antisense oligonucleic acid to the Notch gene as an active ingredient.;COPYRIGHT: (C)2001,JPO