2 - alquilheterodihidropirimidina Derivatives, Process for their PreparationPharmaceutical compositions containing Said derivatives and the use of dichosderivados and compositions as LIGANDS FOR neuronal n-type calcium channels.

摘要

2-asphaltopyridine, including formula I, including its ceramic form 3,4-dihydropyridine, wherein R1 represents sr6, nr6r7 or or6; R2 represents C1-6 tar or c2-6 unsaturated tar, including optional or s, and substituted by phenyl or monocyclic isomeric grass, aromatic ring The alternative is one or more independently selected intermediate halides, C1-6 tar or alcoxi C1 A6 alternatives; R3 represents a single or double ring aromatic ring, optionally adding a hetero selected from n, or s,Selectively substituted with one or more substitutes independently selected among halogen, C1-6 tar, alcoxi C1-6, cyanogen, trifluoromethyl, amine, hydroxy, nitro or carbohydrate; R4 and R5 represent pyridine, morphine, morphine, 3.4-dehydrated pyridine, endosulfan, pyridylene, n-methylpyridylene, pyridine additive substitutes In n-4, C1-6 tar; R6 and R7 independently represent C1-6 ocycloqiulo C3-6 or bencilo tar, optionally substituted by C1-6 Alcoy, alcox C1-6 or halide; X represents o, s or nr8; R8 represents hydrogen or C1-6 tar; n represents 2-4 block;Its optical and racemic isomers and pharmaceutically acceptable salts; processes for the preparation of compounds containing these substances, and its use as a counterpart for n-type neural calcium channels for the treatment of cerebral ischemia and pain. Comment more than a month ago