Beta tiopropionilaminoacidos Derivatives, Pharmaceutical compositions containing such Derivatives, Process for preparing them,Use of dichosderivados for Treatment of bacterial infections and intermediaries in the Composite Application procedure

摘要

Derivatives of beta-mercapto amino acids and solvates or pharmaceutically acceptable in vivo hydrolysable esters of formula (I) in which R is hydrogen, a salt-forming cation, or an in vivo hydrolytable ester forming group; R1 is deformul a (II) where A is a monocyclic aryl or a heteroaryl ring, and B is a monocyclic aryl, an alicyclic or heterocyclic ring, C and D are independently -Zp (CR8R9) q -O - (CR8R9) q-Zp , where p is O or 1,Q is 0 or 3, if P + Q in C is not o, R8 and R9 are independent hydrogen or asphalt (C18),Or add together to represent oxo, YZ is O, nr10 or s (o),Where R10 is hydrogen tar (C1-6),X is 0-2, where C and D are combined at each or the orthogonal position between ring a and brominated diphenyl ether (b);R2 is hydrogen, pitch (C1-6) or aril acquilo (C1-6) R3 is hydrogen, pitch (C1-6) can be selectively replaced by up to three dehalogeno, cycloquilo (c3-7) atoms,1. Aril cycloquilo (c3-7) capacitor, asphalt cycle (c3-7) asphalt (c2-6) alquenilo (c2-6),Penicillin (c2-6),aryl, aryl- (CH2) mX- (CH2) N, heterocyclyl or heterocyclyl- (CH2) mX- (CH2) n, where m is O to 3, n is 1 to 3, and X is O, S (O) x, where x is 0-2 or a link; R4 is hydrogen, or an in vivo hydrolyzable group and R5 and R6 are independently hydrogen and (C1-6) alkyl or together represent (CH2),where r is 2 to 5 salts, solvates, esters.Useful in the treatment of bacterial infections in human animals, by administration together with a beta-lactam antibiotic.Also the synthesis of such derivatives and other advanced objects in the Title.