A Poly (ethylene glycol) with star shape, heterofuncional, biocompatible, production method thereof and Method for conjugate with a protein

摘要

Poly (ethylene glycol) consists in a Star shaped heterofuncional, biocompatible, which responds to the formula [(X - M - Z ch2ch2o)] - N - [(ch2ch2o)] X is bdonde aldehyde, carboxyl, Amine, thiol,Halogen or epoxide; Z represents links amide or Ester carbonate,; M and N are integrated desdeaproximadamente ranging between 10 to 2000: is an integrated approx. 1 to 5 and B is an integrated approx.1 to 100. Is also A method to obtain dichopoli (ethylene glycol) with biocompatible estrellaheterofuncional shape, comprising a First.Step which synthesizes a First ARM composed of a Poly (ethylene glycol) Allyl end Group through Ring Opening polymerization of ethylene oxide initiated with a Salt metu00e1l icadealquenoL; a 2nd. Step termination of Synthesis by reaction with acid to obtain a Terminal Hydroxy Group; 3.Step Activation terminal Hydroxy Group by reaction with a compound containing a Plurality of multi hydroxyl groups; a Fourth.Step Synthesis of unapluralidad ARM branched Poly (ethylene glycol) by polymerization of ethylene oxideWhere each Plurality of branched Arms depoli (ethylene glycol) is linked to the pluralities of hydroxyl groups, obtaining a Star shaped Poly (ethylene glycol), heterofuncional,Containing an Allyl Group final.Is also A method to combine the Poly (ethylene glycol) with star shape, heterofuncional, biocompatibleComposed of a carboxyl terminal Allyl group or a group with a Protein containing a thiol group or an amino Group.