A double Mutation enterotoxin compositions useful as adjuvants.The preparations and compositions containing it together with an Antigen and a Kit useful for the production of a protective immune response against a pathogen in a host

摘要

It describes an ingredient, including a mutation genetically different from E.coli (LT) hot lactic acid macaroni. Specifically, the mutation called LT (r192g / l211a) is changed by two amino acid substitutes, for example, arginina with 192 amino acid positions is replaced by glycerin, and white blood element in glycerin is replaced. The amino acid position 211 was replaced by alachlor. e. The pyrolytic holotoxin of E.coli mutation showed the immune activity of adyuvante, and its toxicity was much lower than that of E.(b) Compared with the natural perfluorooctane sulfonate macaroni produced by e.c.l.l.l. in the El Ensayo of mice, the toxicity was significantly lower; and (c) was lower than the separate LT (r192g) component measured in the mice experiments. It can be transmitted with antigens of bacteria, fungi, protozoa, viruses, worms and other microbial pathogens. It also describes preparations and ingredients containing the substance, as well as an antigen and an effective tool kit to produce an immune response of the host to the source of the disease.