Monoclonal antibody and its Fragments that are directed against cells with INTEGRINS alfavbeta hybridoma Cell Line which producedicho antibodyThe pharmaceutical compositions containing them, a process for their Preparation and the use thereof in tumour processes

摘要

A monoclonal antibody and its fragments have the following characteristics: they react only with the alfav chain of alfaavhuman integrity, and selectively prohibit binding to the cellulose substrate of alfavbeta6 carrier group. The name of hibridoma cell line is 2714d9.f8, which is stored on the access number of DSM acc2331,And it can produce a monoclonal antibody like the top. A pharmaceutical ingredient that includes a monoclonal antibody, such as a description and a vehicle that is superficially acceptable. A procedure for producing monoclonal antibodies, as described above, through mouse immunity with human tumor M21 cell lines. The best way to get cancer treatment by monoclonal antibody is to use a colon cancer cell opulmon,Excluded the location and diagnosis of tumor growth The technical situation describes antibodies against all alfavbeta3 or alfavbeta5 complexes, but does not describe any reagents that selectively inhibit alfavbeta6 series. This is why the present invention provides a monoclonal body, which only reacts with the AV chain of alfav alfav letter of alfav human integrity, selectively blocking the alliance at deintegrina base of alfavbeta 3 and alfavbeta 6 protocells, so-called 14d9.f8.