monoclonal antibody or antigen-binding fragment thereof, isolated nucleic acid molecule, vector, host cell, method for making monoclonal antibody or antigen-binding fragment thereof, conjugate, antibody conjugate hybridoma cell strain lt005 bifunctional, multispecific antibody, pharmaceutical composition and use of the monoclonal antibody or antigen-binding fragment thereof

摘要

The present invention belongs to the field of tumor therapy and molecular immunology and relates to a pdl-1 antibody, a pharmaceutical composition thereof and use thereof. in particular, the present invention relates to a pdl-1 monoclonal antibody or antigen-binding fragment thereof, wherein the monoclonal antibody has a heavy chain variable region comprising cdrs as represented by: 15-17 ; and / or have a light chain variable region comprising cdrs as depicted in sequence: 18-20. The monoclonal antibody of the present invention may specifically bind to pdl-1 and specifically remove pdl-1 immunosuppressive function and activate t-lymphocytes.