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A process for the production of oxalate (1R, 2R - ciclohexanodiamina) Platinum (ii)
A process for the production of oxalate (1R, 2R - ciclohexanodiamina) Platinum (ii)
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机译:草酸盐(1R,2R-环己二胺)铂(ii)的生产方法
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摘要
A procedure for the manufacture of (1R, oxalate- ciclohexanodiamina 2R) - Platinum (ii) to proceed according to the following steps: a) treating an aqueous solution of a neutral Salt of high Optical purity of (1R, 2R) - ciclohexanodiamina,Preferably with two equivalentesde tartrate, an aqueous solution of Sodium Hydroxide, having obtained such apyrogenic aqueous solutions using DISTILLED WATER.(b) the solution of the acuosaresultante phase is mixed with an aqueous solution of Potassium tetraiodoplatinito (i4ptk2) obtained using distilled Water and apyrogenic, (1R,2R) - ciclohexanodiaminadiiodoplatino (ii) (Compound d) precipitated and separated by Filtration (Scheme i).(c) the Petticoat apyrogenic Compound D was suspended in distilled and is treated with an aqueous solution of SILVER NITRATE apyrogenic obtained using DISTILLED WATER.Heating and stirring during the time necessary to transform all the iodine Compound D Silver iodide.The resulting mixture is cooled and filtered, and the solucionacuosa thus obtained contains nitrate (1R, 2R) - ciclohexanodiamindiacuoplatino (ii).(Scheme 2); (d) to the aqueous solution of Nitrate of (1R, 2R) - ciclohexanodiadiamincuoplatino (ii) is added directly and, at room temperatureAn excess of Aqueous solution of Potassium oxalate obtained using aguadestilada apyrogenic and few minutes oxalate crystallizes the final product (1R, 2R - ciclohexanodiamina) Platinum (ii)(Scheme 3); (e) to separate the - (1R, 2R - ciclohexanodiamina) Platinum (ii) CRYSTALLIZED In Step (d).Proceeding according to the steps (a) to (e) gives the oxalate (1R, 2R - ciclohexanodiamina) Platinum (ii) with excellent yield and optical Purity, and Free piretogenos.The Product Manufactured by the process has Application anteriormentemencionado Therapeutic Oncology and is particularly indicated for the treatment of solids, such as the blastomasColon.
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