OPTICALLY HIGH-PURITY CIS-OXALATE (TRANS-L-1,2-CYCLOHEXANEDIAMINE) PLATINUM (II) COMPLEX AND ITS PRODUCTION

摘要

PURPOSE:To obtain a optically high-purity cis-oxalate(trans-1,1,2- cyclohexanediamine)platinum (II) complex useful as an original medicine for carcinostatic agent, etc., showing anticancer properties, having no toxicity, prepared from trans-1-1,2-cyclohexanediamine optically resolved by high- performance liquid chromatography. CONSTITUTION:trans-1-1,2-Cyclohexanediamine optically resolved by high- performance liquid chromatography or its derivative is used as a raw material and reacted with a tetravalent platinate (e.g. potassium chloroplatinate) to give a tetrahalogeno(trans-1-1,2-cyclohexanediamine)platinum (IV) complex of formula I (X is halogen). Then, the platinum complex is suspended in water, reacted with silver oxalate to give the objective cis-oxalate(trans-1-1,2- cyclohexanediamine)platinum (II) complex of formula II, showing anti-cancer properties but not toxicity, =99.94%e.e. optical purity and 198.3-199.7 deg.C melting point.