Derivatives of 2 - aryl - 8 - oxodihidropurina, procedures to prepare, apply in such procedures intermediaries Compounds, Pharmaceutical compositions,And their use for the preparation of a Medicament for the treatment of anxiety States.

摘要

2-aril-8-oxodihydropurina derivative separated from formula (I): W is a hydrogen atom, a lower tar group, a dehalogeno atom, a lower alcox group, an amino group, a lower mono or di hydrocarbon amino group, an alternative or unsubstituted phenyl group; X is an atom, a lower tar group, 1. One cyclopropyl low tar group, one substituted or unsubstituted low phenyl low tar group, one alquenilon group, one carbamoyo group, one ungru Po diacquilo low carbon group or one formula group (q): "CH (R3) con (R1) (R2) (R1 refers to low tar group, ungrupo alquenilo low carbon group, cyclopropyl)1. A cyclopropyl low tar or a flow through asphalt, R2 is a wingold or low tar, a cyclopropyl, an alternative or unsubstituted phenyl low tar, an alternative or unsubstituted phenyl low tar, or an alternative or unsubstituted heteromorphic group, Or R1 and R2 can be combined to form a piston ring, a Pirolli ring, a ring or a Pierson ring with the adjacent atom nit rogeno. These optional rings can be replaced by one or two lower tar groups, while R3 is an H atom, 1. Low asphalt or low asphalt group;It's an H atom, a lower tar group, a cyclopropyl compound, a cyclopropyl tar group, a lower alquenilo group, a lower phenyl tar group, substitution or abandonment,Or a set of formulas (q): - CH (R3) con (R1) (R2),Among them, R1, R2 and R3 are the types previously defined; a is a substituted or unsubstituted phenyl group, or a substituted or unsubstituted heteromorphic group; if x and old formula R (I) are still one, it is a development group,So, the other is one of the same groups, X or Y, as described, except for formula groups,Or a salt that's medically acceptable They also advocate the preparation of these compounds and the above secondary substances. These derivatives are used in medicine because of their selective activity