Substituted tricyclic compounds useful as inhibitors of sPLA2 mediated release of fatty acids in mammals and the use of said compounds in the manufacture of compositions for alleviating LPathological effects of sPLA2 related diseases

摘要

It is recommended to use a tricyclic compound and use it to inhibit the release of fatty acids mediated by sPLA2 to treat diseases such as chemical shock. The above tricyclic compounds refer to formula (I),Where: A is phenyl opiridilo, where the nitrogen is in the position of 5, 6, 7 or 8; B or D is nitrogen, and the other is carbon; Z is cyclohexane, phenyl, pyridine, where the nitrogen is in the position of 1, 2 or 3; or a 6-ring heterocyclic ring with an heteroatom selected from the sulfur compound group. In position 1, 2 or 3, and nitration in position 1, 2, 3 or 4, line 1 is a simple or double link, R20 is selected from the group,(b) And (c),(a) Is (a) C5-20, alquenilo C5-20, C5-20, carbon-20 condensate, carbon thyroid or heterocyclic radicals, or (b) is (a) a member replaced by one or more non interfering substitutes selected independently; or (c) is (L) - R80; in (L) is an entire array of 1 to 12 atoms, 1. Choose from carbon, hydrogen, nitrogen and sulfur; in the combination of atoms in (L), choose from (I) carbide and hydrogen (II), (III) one sulfur, (I V) one oxygen, (IV) one or two nitrogen and one hydrogen, (V) carbon, one hydrogen, one sulfur, and (VI) carbon, one hydrogen and one oxygen;R80 is a group selected from (a) or (b);R21 is a non-interference substitute; R1 is - nh2-nh2-nh2-o-conh2; R2 is selected from a group consisting of - oh y-o (CH2) Tr5, wherein R5 is h-cn-nh2-conh2-conr10-nhs2r15; conhs2r15 is - C1-6 o-cf3 tar; benilo or fenilo is replaced by - CO2H or - co2-tar C1-4; and - (a group) acid,Where - (a) is an acid connector with a length of 1-7 and a t of 1-5; R3 is selected from non interfering alternatives, carbon thyroid radicals, carbon thyroid radicals and non interfering alternatives, Heteromorphic and heteromorphic radicals replaced by non interfering substitutes; or