Strategically modified hepatitis b core protein conjugate, protein particle, protein particle conjugate, immunogenic fusion protein conjugate, inoculum, and, process to induce antibodies in an animal host

摘要

"CONJUGATE OF STRATEGICALLY MODIFIED HEPATITIS NUCLEUS PROTEIN B, PARTICLE OF PROTEIN, CONJUGATE OF PROTEIN PARTICLES, IMMUNOGENIC FUSION PROTEIN CONJUGATE, INOCULATION, AND PROCESS TO INDUCE ANYTHING. A strategically modified hepatitis B core protein is described, where an insert is provided, preferably in an immunodominant region of the nucleocapsid protein, containing a chemically reactive amino acid residue. The modified hepatitis B core protein or its aggregated nucleocapsid protein particles can be pendently linked to a hapten to form a modified nucleocapsid conjugate. This conjugate is usable in the preparation of vaccines or antibodies. The modified hepatitis B core protein can also be modified to include a T cell epitope.