Axially chiral heterocycles based on 3-substituted 1,1'-binaphthalene-2,2'-diols

摘要

The present invention relates to axial chirality derivatives 1, in 4-naphtholdiazepines general formulas II: R indicates that hydrogen or straight chain, ring-type or branched alkyl contain 1 to 6 carbon atoms, Ri1 and Ri2 indicates the alkyl that hydrogen or straight chain, ring-type or branched alkyl contain 1 to 6 carbon atom, or phenyl, or Ri1 and Ri2 linkages and represent-(CHi2) input, wherein n=1 to 6. The preparation method of above-mentioned derivative is further disclosed, the method is characterized in that optically-active or racemic dietheryl esters 2,2 dihydroxy, is handled under 1 '-binaphthalene-3-carboxylic acid at raised temperature with excessive 1,2-diamines.