CYANOGUANIDINE DERIVATIVES AND PHARMACEUTICAL K-CHANNEL BLOCKER COMPOSITIONS CONTAINING THEM

摘要

A compound of the formula (I) or its pharmaceutically acceptable acid addition salts wherein n is 0 or 1, R1 is hydrogen or methyl; R2 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C5 cycloalkyl, C3-C5 cycloalkenyl, hydroxy, methyl, methoxy-C1-C5 alkyl, or R1 and R2 are combined to form a C3-C6 carbocyclic ring; R3 and R4 are each independently selected to be hydrogen, C1-C4 alkyl, F, Cl, Br, I or CF3; R5 is hydrogen, F or Cl; R6 is H, Cl, Br -NH2, -NHCH3, -NHC2H5, -NHCH(CH3)2, -N(CH3)2, -N(C2H5)2, NH(CH2)m -OC1-C3 alkyl (where m is 2 or 3), -NHC(O) C1-C3 alkyl, with the proviso that when R2 is C1-C6 alkyl, then R6 is not H, Cl or Br and n is 0 or 1, or wherein the compound of formula I is (R) N)-Cyano- (3-pyridyl)-N(- (1-phenylpropyl) guanidine or N)-Cyano-N- (3-pyridyl)-N(- [1-(3-chlorophenyl) propyl] guanidine. 4 ט" ז בטבת התשס" א - January 11, 2001