A NOVEL APPROACH TO THE CONVERSION OF 2-(METHYLTHIO)--5-(TRIFLUOROMETHYL)-1,3,4-THIADIAZOLE (TDA) TO 2-(METHYLSULFONYL)-5-(TRIFLUOROMETHYL)-1,3,4-THIADIAZOLE (TDA SULFONE)

摘要

A process for making 2-(methylsulfonyl)-5- (trifluoromethyl)-1,3,4-thiadiazole comprising oxidizing 2-(methylthio)-5- (trifluoromethyl)-1,3,4- thiadiazole in a reaction mixture containing an oxidizing agent, boric acid, and glacial acetic acid, wherein the molar ratio of glacial acetic acid to 2-(methylthio)-5- (trifluoromethyl)-1,3,4- thiadiazole is from about 0.1:1 to about 0.5:1. 1898 ז' באב התשס" ד - July 25, 2004