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IDENTIFICATION AND CHARACTERIZATIONOF INTERACTING MOLECULES BY AUTOMATED INTERACTION MATING
IDENTIFICATION AND CHARACTERIZATIONOF INTERACTING MOLECULES BY AUTOMATED INTERACTION MATING
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机译:通过自动相互作用匹配鉴定和表征相互作用分子
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摘要
The present invention relates to an improved method for the identification and optionally the characterisation of interacting molecules designed to detect positive clones from the rather large numbers of false positive clones isolated by conventional two-hybrid systems. The method of the invention relies on a novel combination of selection steps used to detect clones that express interacting molecules from false positive clones. The present invention provides for high-throughput interaction screens for the reliable identification of interacting molecules, which in turn can lead to the identification of substances inhibiting said interactions. Such inhibitors can find their use in the formulation of a pharmaceutical composition. The present invention further relates to kits useful for carrying out the method of the invention.
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