首页>
外国专利>
INHIBITION OF BINDING OF HOX AND HOME-CONTAINING PROTEINS AND USES THEREOF
INHIBITION OF BINDING OF HOX AND HOME-CONTAINING PROTEINS AND USES THEREOF
展开▼
机译:抑制HOX和含家结合蛋白的结合及其用途
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention demonstrates that BMP-2/4 activates osteopontin gene transcription by removing Hoxc-8 binding through Smad1 interaction with the Hoxc-8 DNA binding domain. Since the DNA binding domain is conserved in all Hox and homeodomain-containing proteins, Smad1 likely interacts with all Hox or homeodomain-containing proteins. Furthermore, the present invention reveals the Smad1-mediated transcriptional mechanism in the BMP-2/4 signaling pathway and also provides information about the transcriptional roles of the Hox genes during embryonic development.
展开▼