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Oral vaccination to suppress hip dysplasia. Oral vaccination to prevent hip dysplasia.

机译:口服疫苗可抑制髋关节发育不良。口服疫苗可预防髋关节发育不良。

摘要

The invention discloses means and methods for determining whether a tissue sample or an analogue and/or derivative thereof comprises a cell with a chromosome {11:18} translocation associated with malignancies such as mucosa-associated lymphoid tissue (MALT) lymphoma's. The invention further provides insight into a novel mechanism of transformation of primary cells. Said mechanism involving expression of a fusion proteinaceous molecule comprising at least apoptosis inhibitor 2 (API2) or a functional part, derivative and/or analogue thereof fused to at least one other proteinaceous molecule. The invention also provides a novel nucleic acid sequence and proteinaceous molecule expressed from said sequence termed MALT-lymphoma associated Translocation (MLT) protein.
机译:本发明公开了用于确定组织样品或其类似物和/或其衍生物是否包含具有与诸如粘膜相关淋巴组织(MALT)淋巴瘤的恶性肿瘤相关的染色体{11:18}易位的细胞的手段和方法。本发明进一步提供了对原代细胞转化的新机制的见解。所述机制涉及表达至少包含凋亡抑制剂2(API2)或其与至少一个其他蛋白质分子融合的功能部分,衍生物和/或类似物的融合蛋白质分子。本发明还提供了由所述序列表达的新颖的核酸序列和蛋白质分子,称为MALT-淋巴瘤相关易位(MLT)蛋白。

著录项

  • 公开/公告号NL1015039C1

    专利类型

  • 公开/公告日2000-11-28

    原文格式PDF

  • 申请/专利权人 GIDON DORMANN;HENK JOHAN GRANDE;

    申请/专利号NL20001015039

  • 发明设计人 GIDON DORMANN;HENK JOHAN GRANDE;

    申请日2000-04-27

  • 分类号A61K35/32;A61K38/39;C07K14/78;A61P19/00;

  • 国家 NL

  • 入库时间 2022-08-22 01:24:45

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