Intravenous Tranexamic acid has been shown to decrease blood transfusion requirements in sur- gery. Little evidence exists regarding the much cheaper oral form. The objective of this cohort study was to evaluate whether oral tranexamic acid administration in patients undergoing elec- tive hip and knee replacement surgery resulted in decreased transfusion requirements. Methods: We assessed the transfusion requirements of 332 patients following unilateral total hip or knee arthroplasty, with the first 140 receiving no tranexamic acid and the next 192 given 1 g oral tranexamic acid one hour prior to and a further 1 g 4 hours post joint arthroplasty. Haemoglobin before and after surgery, the number of units transfused post-operatively and the incidence of deep vein thrombosis or pulmonary embolism were recorded. Results: In the first group, there were 22 instances of transfusion (15.7%) and a mean haemoglobin drop of 32.2 g/L, while the second (tranexamic acid) group had just 12 patients transfused (6.3%) and a mean haemoglobin drop of 24.6 g/L (both significantly less, p < 0.01). There was no significant difference in deep vein thrombosis or pulmonary embolism rates between groups. Conclusions: This is the first prospective study to analyze the outcome of oral tranexamic acid administration in hip and knee replacement. We conclude that oral tranexamic acid administration is a safe and effective means to decrease transfusion requirements in joint arthroplasty and is a much cheaper alternative to intravenous preparations of tranexamic acid.
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机译:Isolated Polyethylene Insert Exchange for Flexion Instability After Primary Total Knee Arthroplasty Demonstrated Excellent Results in Properly Selected Patients
机译:Isolated Polyethylene Insert Exchange for Flexion Instability After Primary Total Knee Arthroplasty Demonstrated Excellent Results in Properly Selected Patients
机译:Incidence of Deep Vein Thrombosis and Its Natural History Following Unilateral Primary Total Knee Replacement in Local Chinese Patients—A Prospective Study 本地中国籍患病者接受单侧全膝关节置换后出现深部静脉栓塞的发病率和自然史– 一个前瞻性研究
机译:初步提交:Embryotoxische Untersuchungen Zur postnatalen Entwicklung Uberzahliger Rippen a Ratten Nach Oraler Verab * W / tsca Health&safety study Cover sheet 062399。